Subchronic (GLP or Non-GLP)

Subchronic toxicity studies are repeat-dose studies usually ranging from 5 days to 6 months. Results of these studies are used to predict appropriate doses of the test substance for more definitive repeat-dose studies, or chronic toxicity studies, and to help determine the MTD and NOELs for selected toxicology endpoints including target organs.  Data from subchronic studies in rodent and non-rodents are used to aid in the determination of doses, routes, formulations, and regimens to be used in potential clinical studies.  Non-GLP subchronic studies use a minimum number of animals and end-points and are intended to provide data used to make a go/no-go decision with respect to more a GLP study or more definitive studies. Species available include mice, rats, hamsters, guinea pigs, rabbits, canine, swine, sheep, poultry, and large farm animals.