Neurotoxicity Studies (GLP and Non-GLP)

Also known as Behavioral studies, are conducted to study the potential of a substance to be a neurotoxin which alters the normal activity of the nervous system. This can eventually disrupt or even kill neurons, key cells that transmit and process signals in the brain and other parts of the nervous system. Symptoms may appear immediately after exposure or be delayed. They may include limb weakness or numbness, loss of memory, vision, cognitive and behavioral problems and sexual dysfunction.  Non-GLP neurotox studies use a minimum number of animals and end-points and are intended to provide data used to make a go/no-go decision with respect to the a potential GLP study in the animal model chosen.  Species available include mice, rats, rabbits, and canine.